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ACS
South Jersey Local Section Meeting
February 2013
Dinner Meeting
February 19,
2012
“Nanoscale
Lipid Systems for the Investigation and Delivery of Biological Molecules”
Dr. Andrew Shaw
Merck, Inc.
Place:
The Telford Inn
145 Bridgeton Pike
Mantua, New Jersey 08051
856-468-0535
http://telfordinn.com/
Agenda:
5:30-6:30 P.M. Social Hour
6:30-7:30 P.M. Dinner
7:30 P.M. Seminar
$20 for members & guests
$10 for students
Bio/Abstract: Andrew Shaw (Andy) did his
undergraduate studies at MidAmerica Nazarene
University in Olathe, KS. He did his
graduate work in the Chemistry department of the University of Illinois at
Urbana-Champaign where he joined the Chemical Biology program as a Roger Adams
Fellow. Upon completion of his doctoral
work in 2007, Andy accepted a position with Merck & Co. at their West
Point, PA facility where he is currently a Sr. Scientist. He has worked in various departments at Merck
including Protein Therapeutics, Parenteral Formulations, and RNA Therapeutics.
Biological molecules continue to increase in importance as novel pharmaceutical therapeutics and in assays for small-molecule drugs. The targets of many pharmaceuticals are membrane proteins which control cellular processes such as signaling and transportation across the membrane as well as enzymatic reactions and cellular adhesion. However, these proteins have proven difficult to study in the absence of the cellular membrane. One novel technology being utilized to overcome these difficulties is Nanodiscs, which consist of a lipid bilayer encircled by an amphipathic helical protein. These soluble systems have a diameter of approximately 10 nm with a lipid bilayer having properties similar to a cellular membrane. Nanodiscs have been used to study membrane proteins in ways not possible with traditional lipid systems such as liposomes or micelles. In a therapeutic area of high interest, RNA interference (RNAi), another lipid nano-scale system has become a leading platform in attempting to overcome the difficulties of delivering RNA administered systemically. Lipid nano-particles (LNPs) measuring approximately 100 nm in diameter utilize cationic and other types of lipid to encapsulate and deliver RNA. Advances in the formulation and processing of LNPs could prove valuable in the advancement of RNAi.
The February meeting will be held at Telford Inn in Mantua.
The restaurant is located at 145 Bridgeton Pike, Mantua.
Please call the restaurant at 856-468-0535 for directions if needed. You can
also check their web site at http://www.telfordinn.com/
Dinner selections: Chicken Dijon with Ham, Crab Cakes. Or Fried
Seafood Combo; vegetarian option is available.
Please email your reservation by Friday, February 15. Be sure to indicate your dinner choice!
Email
to Robert Toreki (info@ilpi.com) or Douglas A. Taylor (fishtrek@comcast.net) with your reservation.
(Do Not use the Reply button.)
New Jersey Department of Education Professional Development Provider number = 2538
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