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" Bio-Catalytic Detoxification of Hazardous Waste:
I. Some Organic Fluorophosphates "
Sidney A. Katz, Ph.D.
Rutgers University
Place:
Adelphia Restaurant
1750 Clements-Bridge Road
Deptford NJ 08096
$20 for members & guests
$10 for students
The Speaker: Dr. Sidney Katz received his A.B. in natural sciences from Rutgers University. He earned a Ph.D. in analytical chemistry from the University of Pennsylvania. He did postdoctoral work at Rutgers, University of California at Irvine and at the Philadelphia College of Pharmacy and Science. He has been a Visiting Professor at numerous universities including the Reading University in England, the Debreceni Egyeten in Hungary, the University of Sindh in Pakistan and the University of Fort hare in South Africa. He has been at Rutgers University since 1960. His long publication record includes reviewed articles in Analytical Chemistry, Analytical Chimica and many other journals. He has also published books and book chapters on analytical topics. He has been awarded research funding from NIH, NSF, BUSCH, WPF and others. Dr. Katz was a NSF/AEC Fellow, a NATO Senior Fellow. He has also for many years held USIS Lectureships. In 1986, he held a Fulbright Lectureship. His research program has been focused on the role and fate of trace elements in environmental and biological systems as well as radiochemistry.
Abstract: The preparation and properties of a bacterial phosphatase that safely and efficiently detoxifies some fluoro derivatives of phosphate ester toxicants such as pesticides and nerve agents will be described. A phosphatase extracted from a special strain of Alteromonas was found to hydrolyze O,O-diisopropyl methyl phosphono-fluoridate, O-isopropyl methyl phosphonofluoridate, O-picacolyl phosphone diamino fluoridate, cyclohexly methyl phosphonofluoridate and N,N'-diisopropyl phosphone diamino fluoridate to the corresponding esters of phosphoric acid. The purified enzyme migrated as a 55 kD protein in SDS-PAGE. Optimal O,O-diisopropyl phosphono- fluoridate hydrolysis occurred at pH 8.0-8.4 and 40-45o. Hydrolysis of O,O-diisopropyl phosphonofluoridate was stimulated by Ca+2, Co+2, Mn+2 and Zn+2. The enzyme has potential application to the bio-catalytic detoxification of waste fluorophosphate toxicants.
The March meeting will be held at Adelphia Restaurant in Deptford.
The restaurant is located at 1750 Clements-Bridge Road, Deptford NJ 08096
From Philadelphia, PA and points West: Take I-76 East or I-95 North or South to the Walt Whitman Bridge. Follow Route 42 South to the exit for Route 544 – Deptford, Woodbury, and Runnemede (Exit 12). Follow the exit to the Traffic Light – make a left turn onto Clements Bridge Road (this is divided highway). Go past the first traffic light 300 yards to the Adelphia, which is on your right side.
From North Jersey,
take I295 South to exit 26, take Highway 42/Atlantic City Expressway south towards Atlantic City, follow Route 42 South to the exit for Route 544 – Deptford, Woodbury, and Runnemede (Exit 12). Follow the exit to the Traffic Light – make a left turn onto Clements Bridge Road (is divided highway). Go past the first traffic light 300 yards to the Adelphia, which is on your right side.
From Atlantic City,
take the Atlantic City Expressway to Route 42 North to Deptford Exit to Rte. 41 North, go to traffic light (McDonald's on your left). Make a left onto Clements Bridge Road - go past the next 3 traffic lights - 300 yards to the Adelphia on your right - Deptford Mall will be across the street on your left.
From Rowan, use Route 55 to go to the Deptford Mall, exit and then use the directions
above.
Please call the restaurant at 856-845-8200 for directions if needed. You can
also check their web site at www.adelphiarestaurant.com.
Dinner selections:
Prime Rib, Flounder, and Eggplant Parmesan
Special orders such as low-salt meals must be ordered in advance and may exceed
the $20.00 price.
Please call or email your reservation by Friday, March 17. Be sure to indicate
your dinner choice!
Douglas A. Taylor, (800) 222-0342 Ex440, dtaylor@emdchemicals.com
Martin Schneiderman, 856-384-7295,Schnema@jmusa.com
The information on this page represents that of the South Jersey Section of
the American Chemical Society and not necessarily that of Rowan University.
Robert Newland, Alternate Councilor SJACS, takes full responsibility for the information
presented.