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The Speaker: Dr. Adam Edward Peritz
Department of Biochemistry, Thomas Jefferson University
Ph.D. May 1993 Biophysical Chemistry Thesis advisor: Professor Douglas H. Turner Department of Chemistry, University of Rochester (Rochester, NY)
Master of Science, Chemistry, May 1988, University of Rochester (Rochester, NY)
Bachelor of Science, Chemistry, Syracuse University (Syracuse, NY), May 1986
June 2002 to Present: Technical director, Nucleic Acid Facility. Cancer Center, University of Pennsylvania.
2001 Postdoctoral Research Fellow. Determined the transcriptional profile in colon epithelial cells after treatment with the mineralocorticoid hormone aldosterone. Supervised a graduate student. Advisor: Gerald Litwack. Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107
1999-2001 Postdoctoral Research Fellow. Developed a method to footprint in vivo psoralen/DNA adducts using a ligation mediated PCR technique. Microdissected squamous cell carcinomas from patients treated with PWA in order to detect mutations in the p53 gene. Supervised a graduate student, technicians and a visiting scholar. Advisor: Francis Gasparro. Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA 19107
1997-1999 Postdoctoral Research Fellow. Targeted gene correction in mammalian cells using an RNA/DNAchimericoligonucleotide. Advisor:KyongYoon. Departmentof Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA 19107
1995- 1997 Postdoctoral Research Fellow. NMR of RNA/DNA hybrid duplexes. Advisor: Eric Wickstrom. Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107
1994 Research Assistant. Measured the Donnan coefficient in small DNA duplexes. Advisor: Allison Williams. Department of Chemistry, Swarthmore College,
Swarthmore PA 19081
1991 – 1993 Postdoctoral Research Fellow. NMR of RNA. Measured the binding constants of RNA/protein complexes. Synthesized a modified base used to cross-link RNA and protein. Advisor: Kathleen Hall. Department of Biochemistry and Molecular Biophysics, School of Medicine, Washington University, St Louis, MO 63110
Awards:
1999-2002 NIH Training Grant
1997-1998 Dermatology Foundation Postdoctoral Fellowship
Recent Publications:
1 Brown, D. B., Peritz, A. E., Uitto, J., and Gasparro, F. P. Ultraviolet-filtering
properties of commonly used tissue cell culture plasticware. Photodermatol
Photoimmunol Photomed. (2001) 17,126-9.
2 Brown, D. B., Peritz, A. E., Mitchell, D. L., Chiarello, S., Uitto, J., and Gasparro, F.
P. Common Fluorescent Sunlamps are an Inappropriate Substitute for Sunlight.
Photochem. Photobiol, (2000), 72, 340-4.

The Talk: The chemical synthesis of DNA oligonucleotides has revolutionized many areas of biological sciences. DNA and RNA are synthesized in solid-phase by the sequential addition of nucleoside-3'-phosphoramidites. The solid-phase method is rapid, cost effective, allows for automation and can be used to modify DNA (e.g. fluorescent labeling). Chemically synthesized DNA is a critical component in many biological techniques such as PCR and DNA sequencing. DNA microarrays contain thousands of small oligodeoxynucleotides on a silicon chips or glass slides. The physical characteristics of DNA can be used in other scientific areas. Researchers are working to incorporate oligonucleotides into electronic circuits, while others are trying to develop "DNA computers" in order to solve complex problems.

The October meeting will be held at Adelphia Restaurant in Deptford.

The restaurant is located at 1750 Clements-Bridge Road, Deptford NJ 08096

From North Jersey, Philly, take I295 to exit 26, take Highway 42/Atlantic City Expressway south towards Atlantic City, and exit onto Highway 55. Take the first exit. Go left at the light and proceed to Clements-Bridge Road. Turn right. The restaurant is on the left side of the road and will require you to do a U-turn.

From Atlantic City, take the AC Express way to the Route 322 exit. Go through Rowan campus to route 55. Take Route 55 north to the Deptford Mall exit. Use directions above.

From Rowan, use Route 55 to go to the Deptford Mall, exit and then use the directions above.

Please call the restaurant at 856-845-8200 for directions if needed. You can also check their web site at www.adelphiarestaurant.com.

Dinner selections:
Baked Filet of Flounder with Lemon Butter Sauce
Veal Parmigiana or Bread Milk-Fed Veal Topped with Mozzarella Cheese &
Tomato Sauce or Vegetarian Meal
Special orders such as low-salt meals must be ordered in advance and may
exceed the $20.00 price.

Please contact one of the people below by Friday, October 17.

Peter Mlynek (856) 787-0770 or pdmlynek@yahoo.com
Guenter Niessen (856) 423-6300 or gniessen@emscience.com
Michael Casner, 856-384-7048 or casnerm@jmusa.com