The speaker:

Dr. Marisa C. Kozlowski

Assistant Professor of
ORGANIC AND BIOORGANIC CHEMISTRY

A.B. Cornell University (1989)
Ph.D. University of California, Berkeley (1994)
NSF Postdoctoral Fellow, Harvard University (1995-96)

email: marisa@sas.upenn.edu

The talk:

We have explored the use of computational tools including: fragment mapping, database mining, and transition state modeling in the design of ligand architectures for asymmetric synthesis. The development of chiral auxiliaries and catalysts by screening stereochemical descriptors against three-dimensional databases such as the Cambridge Crystallographic Database will be presented. For example, novel chiral ligands based upon a cis-decalin core have been identified using this method. Bifunctional chiral catalysts consisting of salen metal complexes incorporating Bronsted or Lewis bases were also designed and have proven effective in asymmetric Michael reactions and the asymmetric alkylation of aldehydes and ketoesters.

The Februrary meeting will be held at the Howard Johnson Hotel and Bombay Cuisine, 2389 Rt 70 W, Cherry Hill, NJ 08002. Phone 856-317-1900 & 856- 596-1200. These two places are next to each other.

Directions to the meeting place are listed below.
From South Jersey: Take 295 N, exit at 34 B towards 70W. Go on 70 W for about 4.5 miles. Stay on the right lane once you pass Hilton on your left. Pass Howard Johnson Express Inn on your left and take the jug handle immediately after the light to get onto 70 E. Stay on the right. Howard Johnson Inn/ Bombay Cuisine is on your right in between Lexington and Donahue Ave.

From Central City PA: Follow 676 E towards Ben Franklin bridge. Follow the sign to Rt 30 and 70 E. Stay on 70 E for about 2.5 miles. The restaurant is on your right after Lexington Ave.

Your favorite driving direction can be found on MapQuest.com by using the above address.

Social Hour: 5:30-6:30 PM at Banquet Hall, Howard Johnson
Dinner: 6:30 PM at Bombay Cuisine
Talk 7:30 PM at Banquet Hall, Howard Johnson

Dinner is a special Indian buffet including Salad; Appetizer (Sheesh Kabob/ Tandori Chicken); Main food (Chicken Tikka Masala & Lamb Rogen Ghosh & 2 vegie dishes); Rice; Nan (will provide fresh on the table upon request); Sodas/ Coffee - Tea (need to order at the table); Dessert.

Cost: $15 members and guests, $10 students
Reservations by Monday February 11, 2001

Lori Stephans (856) 256-4500 ext. 3551
Michael Casner (856) 384-7048
Thomas Colacot (856) 384-7185
Cathy Yang (856) 256-4500 ext. 3569