Faculty & Staff

Paola Leone, PhD

Dr. Paola Leone is an Associate Professor of Cell Biology. She directs all research activities at UMDNJ and the affiliated centers. Her research interests have included in vivo neurochemistry of epilepsy and gene transfer approaches for the treatment of neurological disorders. She has published extensively in the field of CNS gene therapy and conducted the first direct gene therapy trial using a liposome-based vector for a pediatric neurodegenerative disorder. In addition to applications of viral vectors and stem cells, Dr. Leone is studying pharmacological approaches in humans and in animal models of Canavan Disease

Paola Leone, PhD

(1994 to date)

During, M.J., Fried, I., Leone, P., Katz, A. and Spencer, D.D. (1994) Direct measurement of extracellular lactate in the human hippocampus during spontaneous seizures.  J. Neurochem. , 62, 2356-2361.

Kaplitt, M.G., Leone, P., Xiao, X., Pfaff, D.W., O’Malley, K.L., Samulski, R.J., and During, M.J. (1994) Adeno-associated virus vectors yield long-term expression of potentially therapeutic genes in the mammalian brain.  Nature Genetics, 8: 148-154.

During, M.J., Leone, P., Davis, K.E., Kerr, D., and Sherwin, R.S. (1995) Glucose availability influences hippocampal GABA release in the freely-moving rat via an effect on ATP-sensitive potassium channels.  J. Clin.  Inv., 95: 2403-2408.

Badiani, A., Leone, P., Noel, M.B., and Stewart J. (1995) Ventral tegmental area opioid mechanisms and modulation of ingestive behavior.  Brain Research, 670: 264-276.

Maggs, D.G., Jacob, R., Langer, R., Leone, P., During M.J., Tamborlane, W.V., and Sherwin, R.S. (1995) Interstitial fluid concentrations of glycerol, glucose and amino acids in human quadricep muscle and adipose tissue: evidence for significant lipolysis in skeletal muscle. J. Clin. Inv., 96: 370-377.

Wise, P., Leone, P., Rivest, R., and Leeb, K. (1995) Elevations of nucleus accumbens dopamine and DOPAC levels during intravenous heroin self-administration. Synapse, 21, 140-148.

During, M.J. and Leone, P. (1995) Adeno-associated virus vectors for gene therapy for neurodegenerative disorders. Clinical Neuroscience, 3, 292-300.

Jacob R.J., Dziura J., Medwick, M.B., Leone, P., During, M.J., Shulman, G.I., and Sherwin, R.S. (1997) The effect of Leptin is enhanced by microinjection into the ventromedial hypothalamus.  Diabetes 46 (1) 150-152.

Freese, A., Kaplitt, M.G., O’Connor, W.M., Abbey, M., Langer, D., Leone, P., During,M.J. (1997) Direct gene transfer into human epileptogenic hippocampal tissue with an adeno-associated virus vector - implications for a gene therapy approach to epilepsy. Epilepsia, 38: 759-766.

During, M.J. and Leone, P. (1997) Targets for Gene Therapy of Parkinson’s Disease: Growth Factors, signal transduction and promoters. Exp. Neurol., 144, 74-81.

O'Connor, W.M., Davidson, B.L., Kaplitt, M.G., Abbey, M.V., During, M.J., Leone, P., Langer, D., O'Connor, M.J., Freese, A. (1997) Adenovirus vector-mediated gene transfer into human epileptogenic brain slices: prospects for gene therapy in epilepsy. Exp. Neurol. 148, 167-78.

During, M.J., Samulski, R.J., Leone, P., Kaplitt, M.G., Freese, A. Xiao, X., Elsworth, J.D., Roth, R.H., Sladek, J.R.Jr., O'Malley, K.L. and Redmond, D.E. (1998) In vivo expression of therapeutic human genes for dopamine  production in the caudates of MPTP-treated monkeys using an AAV vector. Gene Therapy  5, 820-827.

During, M.J., Xu, R., Young, D., Kaplitt, M.G., Sherwin, R.S., and Leone, P. (1998) Peroral gene therapy of lactose intolerance using an AAV vector. Nature Medicine, 4, 1131-1135.

Young, D.D., Lawlor, P., Leone, P., Dragunow, M., During, M.J. (1999) Environmental enrichment inhibits spontaneous neuronal apoptosis and prevents neuronal injury in the rat. Nature Medicine, 5, 448-453.

Leone, P., Janson, C.G., McPhee, S.J., During, M.J. (1999) Global CNS Gene Transfer for Childhood Neurogenetic  Enzyme Deficiency: Canavan Disease. Current Opinions in Molecular Therapeutics, 1:4, 487-492

Janson, C.G., McPhee S.W.J., Leone, P., During, M.J. (1999) Gene Therapy in the Central Nervous System. Science and Medicine, 6,4-5.

Leone, P., McPhee, S.W., Janson, C.G., Davidson, B.L., Freese, A., During, M.J. (2000) Multisite partitioned delivery of human tyrosine  hydroxylase  gene with phenotypic recovery in Parkinsonian rats. Neuroreport, 2:6, 1145-1151.

During, M.J., Symes, C.A., Lawlort, P.A., Lin, J., Dunning, J., Fitzsimons, H.L., Poulsen, D., Leone,P., Xu, R., Dicker, B.L., Lipski, J., Young, D. (2000) Targeted autoimmunity: a genetic NMDAR1 vaccine with efficacy in experimental stroke and epilepsy. Science, 287, 1453-1460.

Leone, P., Janson, C.G., Bilianiuk, L., Wang, Z., Huang, L., Sorgi, F., Matalon, R., Kaul, R., Zeng, Z., Freese, A., McPhee S.W., Mee, E., During, M.J. (2000) Aspartoacylase gene transfer to the mammalian central nervous system with therapeutic implication for Canavan Disease.  Ann. of Neurol, 48:1, 27-38.

Telfeian, A.E., Federoff, H.J., Leone, P., During, M.J., Williamson, A. (2000) Overexpression of GluR6 in rat hippocampus produces seizures and spontaneous nonsynaptic bursting in vitro.  Neurobiology of Disease, 4, 362-374.

Janson CG, McPhee SW, Leone P., Freese A, During MJ. (2001) Viral-based gene transfer to the mammalian CNS for functional genomic studies. Trends Neurosci. 1;24(12):706-12.

Xu R, Janson CG, Mastakov M, Lawlor P, Young D, Mouravlev A, Fitzsimons H, Choi KL, Ma H, Dragunow M, Leone P., Chen Q, Dicker B, During MJ. (2001) Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes.  Gene Therapy  8 (17):1323-32.

Janson CG, Ramesh T.M., During, M.J., Leone, P., Heywood, J.(2001) Human intrathecal transplantation of peripheral blood stem cells in amyotrophic lateral sclerosis. Hematotherapy & Stem Cell Research 10:6, 913-16.

Abi-Saab W.M., Maggs D.G., Jones T, Jacob R, Srihari V., Thompson J., Kerr D, Leone P, Krystal J.H., Spencer D.D., During MJ, Sherwin R.S. (2002) Striking Differences in Glucose and Lactate Levels Between Brain Extracellular Fluid and Plasma in Conscious Human Subjects: Effects of Hyperglycemia and Hypoglycemia. J Cereb Blood Flow Metab. (3): 271-279.

Janson, C.G, McPhee, S.W.J., Bilaniuk, L., Haselgrove, J., Testaiuti, M., Freese, A., Wang, D.J., Shera, D., Hurh P., Rupin J., Saslow, E., Goldfarb, O., Goldberg, M., Larijani, G., Sharrar, W., Camp A., Liouterman, L., Kolodny, E., Samulski, J., Leone, P. (2002) Gene Therapy of Canavan Disease: AAV-2 Vector for Neurological Delivery of Aspartoacylase Gene (ASPA) to the Human Brain. Human Gene Therapy, 13: 1391-1412.

Janson C.G., Leone P., Freese, A. (2002) Current medical and surgical approaches to Parkinson’s Disease. Science and Medicine. 8:6, 328-338.

Janson C.G., Leone P., Freese, A. (2003) Current medical and surgical approaches to Parkinson’s Disease. Science & Medicine 9(1): 24-35.

 

Janson C.G., Leone P., Freese, A. (2003) Current medical and surgical approaches to Parkinson’s Disease. Science & Medicine 9(2): 82-95.

Zeng, B., Wang, Z-H., Ribeiro, L.A., Leone, P., De Gasperi, R., Kim, S-J., Raghavan, S., Ong, E., Naum, M., Pastores, G.M., Kolodny, E.H. (2003) Identification and Characterization of Novel Mutations of the Aspartoacylase Gene in Non-Jewish Patients with Canavan Disease. Journal of Inherited Metabolic Diseases. 2002; 25: 557-570.

Janson C.G., During M., Shifman Y, Leone P. (2003) Transcriptional Activation of Human CREB gene promoter using bis-PNA (peptide nucleic acid). Letters in Peptide Science. 10 (3), 373-376.

Boulis, N.M., Noordmans, A.J., Song, D.K., Imperiale, M.J., Rubin, A., Leone, P., During, M., Feldman, E. (2003) Adeno-Associated Viral Vector Gene Expression in the Adult Rat Spinal Cord Following Remote Vector Delivery. Neurobiology of Disease. 14(3): 535-41

Janson C.G., Leone P., Freese, A. (2003) Current medical and surgical approaches to Parkinson’s Disease. Science and Medicine. 9(1): 24-35

Janson C.G., Leone P., Freese, A. (2003) Current medical and surgical approaches to Parkinson’s Disease. Science and Medicine. 9(2): 82-95

Boulis, N.M., Noordmans, A.J., Song, D.K., Imperiale, M.J., Rubin, A., Leone, P., During, M., Feldman, E. (2003) Adeno-Associated Viral Vector Gene Expression in the Adult Rat Spinal Cord Following Remote Vector Delivery. Neurobiology of Disease. 14(3): 535-41

McPhee, S.W.J., Francis, J.S., Janson, C.G., Serikawa, T., Hyland, K., Ong, E.O., Raghavan, S.S., Freese, A., Leone, P. (2004) Effects of AAV-2 mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease. Molecular Brain Research. 135(1-2):112-21

Inoue, H., Osawa, I. , Murakami, T., Kimura, A., Hakamata Y., Sato, Y., Kaneko,T., Okada, T., Ozawa, K., Francis J., Leone, P., and Kobayashi, E. (2005) Development of Inbred Transgenic Strains of Rats with LacZ or GFP. Biochemical & Biophysical Research Communication. 329(1): 288-95.

Assadi, M., Janson, C.G., Bilaniuk, L., Shera D., Leone, P. (2005) Case Report: Lithium Citrate for Canavan Disease. Pediatric Neurology. 33:235-243.

Tavazzi, B., Lazzarino, G., Amorini, A.M., Bellia, F., Fazzina, G., Giardinia, B., Leone, P. (2005) Sensitive and reproducible high performance liquid chromatographic separation of N-Acetyl Aspartate, N-Acetyl Glutamate and N-Acetyl-Aspartyl Glutamate suitable for the biochemical evaluation of Canavan Disease patients. Clinical Biochemistry. 38(11):997-1008

Janson, C.G., Kolodny, E.H., Bilaniuk, L., Shera, D., Goldfarb, O., Zeng, B-J., Leone, P. (2006) Mild-onset presentation of Canavan disease associated with novel G212A point mutation in aspartoacylase gene. Annals of Neurology. 59(2):428-31

McPhee, S.W.J., Janson, C.G., Francis, J.S., Samulski, R.J., Freese, A., Shera, D., Leone, P.  (2006) Immunological Profile of Patients Treated With AAV-2 Vectors. Journal of Gene Medicine. 8(5):577-88

Francis, J.S.,  McPhee, S.W.J., Olariu, A., Janson, C.G., Leone, P. (2006) A Role for Aspartoacylase in the Regulation of BDNF and the Timing of Postnatal Oligodendrogenesis. Journal of Neuroscience Research. 84(1): 151-69.

Zeng, B-J., Wang, Z-H; Torres, P.A.,  Pastores, G.,  Leone, P. Raghavan, S.S., Kolodny E.H. (2006) Rapid Detection of Three Large Novel Deletions of the Aspartoacylase Gene In Non-Jewish Patients With Canavan Disease. Molecular Genetics and Metabolism. 89(1-2):156-63.

Zeng, B.J., Pastores G.M., Leone, P., Raghavan, S., Wang Z.H., Ribeiro, L.A., Torres, P., Ong E., Kolodny, E.H. (2006) Mutation Analysis of the Aspartoacylase Gene in non-Jewish Patients in Canavan Disease. Advances in Experimental Medicine and Biology. 576:165-73.

Janson CG, McPhee SWJ, Francis J, Shera D, Assadi M, Hurh P, Haselgrove J, Wang DJ, Bilaniuk L, Freese A, Leone P. (2006) Natural History of Canavan Disease Revealed by Serial MRI and Proton magnetic resonance spectroscopy (1H-MRS). Neuropediatrics.  84(1): 151-69.

Francis, J.S., Olaris, A., McPhee, S.W.J., Kobayashi, E, Leone, P. (2007) GFP-transgenic Lewis rats as a cell source for oligodendrocyte replacement. Journal of Experimental Neurology. 205(1):177-89.

Aghai, Z.H.,  Kode, A.,  Saslow J.G., Nakhla T.,  Farhath, S., Stahl, G.E., Eydelman R., Louise Strande, L.,  Leone, P., Rahman, I. (2007) Azithromycin Suppresses Activation of Nuclear Factor-kappaB and Synthesis of Pro-inflammatory Cytokines in Tracheal Aspirate Cells from Premature Infant. Pediatric Research. 62(4):483-8.

Aghai, Z. H.,  Faqiri, S., Saslow, J.G., Nakhla,  T.,  Farhath, S., Kumar,  A., Eydelman, R.,  Strande,  L., Stahl, G.E.,  Leone P., and Bhandari. V. (2008) Angiopoietin 2 is Increased in Tracheal Aspirates From Premature Infants Developing Bronchopulmonary Dysplasia. Journal of Perinatology. 28(2):149-

Assadi, M., Basemen S., Janson C.J., Wang D-J., Bilaniuk L., Leone P. (2008) Serial 1H-MRS in GM2 Gangliosidoses. European Journal of Pediatrics,. 167 (3):347-52.

Assadi, M., Campellone, J.V., Janson C.G., Veloski, J.J., Schwartzman R.J., Leone, P. (2008) Treatment of Spinocerebellar Ataxia with Buspirone . Journal of Neurological Sciences. 260(1-2):143-146.

Assadi, M., Leone, P., Veloski J.J., Schwartzman R.J. Janson C.G., Campellone J.V.(2008)  Validating an Ataxia Functional Composite Scale in Spinocerebellar Ataxia. Jou rnal of Neurological Science 268(1-2):  136-9.

Wang J., Leone P., Wu G., Francis J.S., Li H., Jain M.D., Serikawa t., Ledeen R.W. (2008) Myelin Lipid Abnormalities in the Aspartoacylase-Deficient Tremor Rat. Neurochemical Research. In press

Dr Leone Profile Pic

 

Zubin Shah, MD, MPH

Dr.Zubin Shah is a Research Consultant at the Cell and Gene Therapy Center. After completing medical school, Dr.Shah also graduated with his Master of Public Health from Harvard University - Boston, MA. He has extensive experience in the field of neuroscience. Dr.Shah has researched on Stroke and is currently working on Canvan Disease. He is an important contributor in writing patient reports, grant writing and submission of manuscripts.

Shah  Profile Pic

 

Mitra Assadi, MD

Dr. Mitra Assadi initially worked at the NIH as a Research Fellow before starting her training in neurology in 1993 at Drexel University in Philadelphia. Upon completing her training in adult neurology in 1997, she did a fellowship in pediatric neurology at the St. Christopher Hospital for Children in Philadelphia. For the past three years, she has been working in Cooper hospital/UMDNJ as an Assistant Professor of Neurology. She is the clinical principal investigator of the lithium and buspirone studies.

Mitra Assadi, MD

Articles, Reviews, and Letters (1998 to date):

Mitra Assadi and Catherine M. Foley, "Refractory Seizures as Presenting Feature of Mitochondrial Cytopathies. Study of 15 Cases", Epilepsia Sup., Dec. 1998

Fernando Aries-Mendosa and Mitra Assadi, "P31 MR Spectroscopy of the Muscle in Neuromuscular Disorders", Annals of Neurology Sup. Sep. 1999

Mitra Assadi and Olga Goldfarb, "Spontaneous remission of periodic discharges in a patient with subacute encephalitis". Epilepsia Sup., Dec 1999

Mitra Assadi and Daniel Hymen, Tc SPECT Scan in a Patient with Complex Visual Hallucinations, Journal of Neuroscience Nursing, vol. 35, April 2003.

Papers in Progress:

Mitra Assadi and Rhonda Schnur, Clinical manifestations in a patient with Ruvalcaba-Myhre-Smith Syndrome, being submitted to Journal of Clinical Neuromuscular disease.

Mitra Assadi and Rhonda Schnur, Unusual Dysmorphic Features in Congenital Myotonic Dystrophy, being submitted to Journal of Pediatrics.

Mitra   Assadi, MD

 

Larissa Bilaniuk, MD (Adjunct)

Dr. Larissa Bilaniuk is a Professor of Radiology at the University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia (CHOP). She is the Principal Clinical Investigator of the clinical gene therapy study funded by a subcontracting grant from the National Institute of Neurological Disorders and Stroke. Dr. Bilaniuk has 15 years of experience as a clinical radiologist at CHOP. She is responsible for the coordination of the study at CHOP as well as the MRI reading during the screening of the patients and during the post-gene transfer follow-up tests.

Dr.   Larissa Bilaniuk

 

Melissa Casas

Ms. Melissa Casas is an Administrative Assistant and Gene Therapy Coordinator for the Center. She assists with patient appointments and follow-up for all clinical studies, as well as other administrative duties.

 

Jeremy Francis, PhD

Dr. Jeremy Francis is an Assistant Professor at the Center with an interest in signal transduction mechanisms relevant to a range of neurological diseases and processes. He is currently involved in the characterization of molecular aspects of brain development relevant to the Canavan Disease phenotype, which aims to identify the fundamental regulatory mechanism responsible for disease progression in affected individuals. He is also investigating aspects of the immune response in the brain with application to neurodegenerative autoimmune disorders.

Jeremy Francis, PhD

Articles, Reviews, and Letters:

During M.J., Cao, L., Zuzga, D.S., Francis, J.S., Fitzsimons H.L., Jiao, X., Bland, R.J., Klugmann M., Banks, W.A., Drucker, D.J., Haile, C.N. (2003) Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nature Medicine 9(9): 1173-9.

Francis, J.S.. Dragunow, M., and During, M.J. (2004) Overexpression of ATF-3 protects rat hippocampal neurons from in vivo injection of kainic acid. Molecular Brain Research  124(2):199-203.

Inoue, H., Osawa, I. , Murakami, T., Kimura, A., Hakamata Y., Sato, Y., Kaneko,T., Okada, T., Ozawa, K., Francis J., Leone, P., and Kobayashi, E. (2005) Development of Inbred Transgenic Strains of Rats with LacZ or GFP. Biochemical & Biophysical Research Communication.

McPhee, S.W.J., Francis, J.S., Janson, C.G., Serikawa, T., Ong, E.O., Kolodny, E.H., Hyland, K., Young, D., During, M.J., Leone, P. (2005) Effects of AAV-2 Mediated Aspartoacylase Gene Transfer in the Tremor Rat Model of Canavan Disease. Molecular Brain Research.

McPhee, S.W.J., Janson, C.G., Francis, J., Samulski, R.J., Freese, A., Shera, D., Leone, P. (2005) Immunological Profile of Patients Treated with AAV-2 Vectors. In Press.

Tavazzi, B., Lazzarino, G., Leone, P., Amorini, A.M., Bellia, Janson, G.J., Di Pietro, V., Ceccarelli, L., Donizelli, S., Francis, J.S.,  F., Giardinia, B., (2005) Sensitive and reproducible high performance liquid chromatographic separation of N-Acetyl Aspartate, N-Acetyl Glutamate and N-Acetyl-Aspartyl Glutamate suitable for the biochemical evaluation of Canavan Disease patients. Clinical Biochemistry. 38(11): 997-1008

McPhee, S.W.J., Janson, C.G., Francis, J., Samulski, R.J., Freese, A., Shera, D., Leone, P. (2005)  Immunological Profile of Canavan Patients Treated With AAV-2 Vectors. Journal of Gene Medicine.
8. . 8(5) 577-588

Francis, J.S., McPhee, S.W.J., Olariu, A., Janson, C.G., Leone, P. A Role for Aspartoacylase in the Regulation of BDNF and the Timing of Postnatal Oligodendrogenesis. Journal of Neuroscience Research.    In Press

Natural history of Canavan disease revealed by serial MRI and proton magnetic resonance spectroscopy (1H-MRS). (2006) Janson CG, McPhee SWJ, Francis J.S, Shera D, Assadi M, Hurh P, Haselgrove J, Wang DJ, Bilaniuk L, Freese A, Leone P. Neuropediatrics. In press

Olariu, A., Francis, J.S., McPhee, S.W.J., Kobayashi, E, Leone, P. GFP- Transgene Lewis Rats as a Cell Source for Oligodendrocyte Replacement.Submitted

Dr   Francis profile pic

 

Biagio Saitta, PhD

Dr. Biagio Saitta is an Adjunct Associate Professor of the Department of Cell Biology at the SOM/UMDNJ. He has developed and directed a research program utilizing multipotent mesenchymal stem cells  (MSCs) obtained from neonatal cord blood. Dr. Saitta has isolated and characterized these human stem cells from a non-controversial source and has directed their differentiation into multiple cell types  including those of muscle, cartilage, and bone. His laboratory has focused on understanding molecular mechanisms involved in tissue repair of these adult stem cells. Dr. Saitta published work has shown  diversity among MSCs and also that they can be used successfully as in vitro models of musculoskeletal development. The current focus is to direct these multipotent cells toward use in regenerative medicine. His expertise in extracellular matrix regulation and in stem cell biology has resulted in collaborative federal grants with Schepens Eye Institute of Harvard Medical School, using MSCs to develop cell-based therapies for disorders requiring corneal transplants. His future goal is to combine the stem cell technology with tissue engineering approaches to develop tissue-specific extracellular matrix-based  grafts for testing in injury repair, both for in vitro and in vivo models.

 Biago Saitta PhD

 

 

Vlad Markov, MD

Dr. Vladimir Markov is a research scientist at the CGTC. His clinical research experience includes leukemia, multiple myeloma, aplastic anemia, myelodysplastic syndromes, and pathological changes in bone Barrow during systemic diseases. He is currently working on the isolation, expansion and characterization of stem cells from various sources. He is also involved in ongoing transplantation experiments at the CGTC that are designed to assess the safety and efficacy of stem cells in animal models of disease.

Vladimir Markov
 

Louise Strande, MS, CCRC

Louise recently joined the Center as a Research Teaching Specialist, after a long career in basic science research.  Following completion of a master’s degree in Cell Biology at the University of Pennsylvania, Louise spent 10 years in a radiation oncology research group at Stanford University, Palo Alto, CA.  After 3 years at Thomas Jefferson University in Philadelphia, Louise spent the last 15 years in the Division of Surgical Research at Cooper University Hospital in Camden, NJ.  She has been active in projects involving screening new cancer drugs, cell culture and tissue engineering, transplant immunology and most recently a grant supported project studying the induction of tolerance to a solid organ transplant in a rat model.  Louise is also a Certified Clinical Research Coordinator having 6 years experience coordinating surgical clinical research trials. 

Louise Strande, MS, CCRC

(10 selected publications of 43)

Strande LF, Foley, Doolin EJ, Hewitt CW. In vitro bioartificial skin model of tissue rejection and inflammatory/immune mechanisms. Transplant Proc, 29(4): 2118-9, 1997.

Chen MK, Strande L, Kain M, Whalen TV, Doolin EJ. Induction of apoptosis in a neuroblastoma and hepatocyte coculture model. J Surgical Res, 78(2): 123-130, 1998.

Beierle EA, Strande L, Geldziler BD, Chen MK. Neuroblastoma and hepatocyte coculture conditioned media alter apoptosis. J Surg Res. 90(2):113-18, 2000.

Beierle EA, Strande LF, Berger AC, Chen MK. VEGF is upregulated in a neuroblastoma and hepatocyte co-culture model. J Surg Res 97(1):34-40, May, 2001.

Doolin EJ. Strande LF. Sheng X. Hewitt CW. Engineering a composite neotrachea with surgical adhesives. Journal of Pediatric Surgery. 37(7):1034-7, July 2002

Tai CY, France M, Strande LF, Eydelman R, Sheng X, Matthews MS, Dalsey R, Hewitt CW. An extraperitoneal isolated vascularized bone marrow transplant model in the rat. Transplantation. 75(9): 1591-1593, May 2003.

Tai CY, Strande LF, Eydelman R, Sheng X, Tran JL, Matthews MS, Hewitt CW. Absence of graft versus host disease in the isolated vascularized bone marrow transplant. Transplantation,77(2): 316-319, 2004

Gordon CR, Matthews MS, Lefebvre DR, Strande LF, Marra SW, Guglielmi M, Hollenberg SM, Hewitt CW. A new modified technique for heterotopic femoral heart transplantation in rats. J Surgical Research, 139(2); 157-163, 2007.

Schuster K, Martens M. Goldenberg M, Tai C, Strande L, Hewitt CW. Production of a novel fibroblast populated platelet matrix co-cultured with keratinocytes. Tissue Engineering, 13(7): 1493-1500 Jul 2007.

Lefebvre DR, Strande LF, Hewitt CW. An enzyme-mediated assay to quantify inoculation volume delivered by suture needlestick injury: two gloves are better than one. Journal American College of Surgeons, 206(1): 113-122 Jan 2008.

 

Abstracts (12 selected abstracts of 84)

Strande LF, Lefebvre DR, Tai C, Matthews MS, Marra SW, Hewitt CW. “Vascularized bone marrow transplantation (VBMT) across a fully allogeneic barrier induces immune chimerism with absence of graft versus host disease (GVHD). ” The FASEB Journal. 2008.

Kopp SA, Strande LF, Lefebvre DR, Matthews MS, Marra SW, Hewitt CW. Decreased expression of IL-2 receptor (CD25) in rat heart allografts with concomitant vascularized bone marrow transplantation (VBMT) . 47th Annual Meeting of the American Society for Cell Biology in Washington, DC, December 1-5, 2007.

Kawata M, Tai CY, Strande L, Eydelman R, Louinev V, Marra S, Matthews M, Hewitt CW. CD4+ CD8+ double-positive lymphocytes associated with tolerance in the isolated vascularized bone marrow transplant model. Proceedings of the 8th International Congress of the Cell Transplant Society, 2006, p.82.

Gordon CR, Strande L, Matthews MS, Marra S, Alexander JB, DelRossi AJ, Hewitt CW.  A new modified technique for heterotopic femoral heart transplantation in rats.  J Reconstr Microsurg, 22(7): 562-563, 2006. 

Tai CY, Strande LF, Lounev V, Hadeed JG, Eydelman R, Matthews MS, Marra SW, Hewitt CW. Vascularized bone marrow transplantation: A new surgical approach to bone marrow transplantation induces immunological tolerance. . Am. J. Transplantation, American Transplant Congress, Seattle, WA, May 21-25, 2005

Careaga E, Strande L, Markov V, Gordon C, Kumar MA, Eydelman R, Marra S, Saitta B, Hewitt CW. In vitro infiltration and potential differentiation of human cord blood mesenchymal stem cells (HCBMSC) in an acellular dermal matrix. The FASEB Journal, 19(4): A230, 2005.

Strande L, Hadeed J, Bellavance E, Kumar S, Tran JVL, Eydelman R., Hewitt CW. Evidence of human microvascular endothelial cell infiltration and capillary formation in bioengineered skin constructs (BHSC). Laboratory Investigation, 84(1):327A, 2004.

Strande, LF, Perlman, NE, Eydelman, R, and Hewitt, CW. Moderate thermal injury triggers elevated CD95(APO-1/Fas) expression in bioengineered human skin constructs. Mol Biol Cell, Vol. 14, p. 63A, 2003.

Schuster KM, Goldenberg M, Tai C, Strande L, Hewitt CW. A novel method for the in vitro production of a human skin equivalent using a platelet matrix. J Surg Res, 100: 283, 2001.

Strande L, Perlman, N, Doolin EJ, Hewitt CW. In Vitro “human” dermal construct engineered with a commercially available acellular dermis. Tissue Engineering 6(6):673, Dec. 2000.

Hewitt CW, Strande L, Tatem L, Hirpara S, Santos M, Black K, Doolin E: Mechanisms of prior blood transfusion-cyclosporine induced tolerance: A role for in situ immune cellular chimerism and local TGF- Expression. Abstracts of the Fifteenth Annual Meeting of the American Society of Transplant Physicians, p. 185, 1996.

Strande L, Doolin, EJ, Zaontz M, Santos M, Hewitt C. Immunochemical analysis of tolerant rat kidney allografts. The FASEB Journal 9(3 pt 1), A436, 1995.

Louise Strande

Cell and Gene Therapy Center
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