Cell Biology & Neuroscience

Faculty and Research Interests

Daniel J. Chandler, PhD

Daniel J. Chandler, PhD

Associate Professor
Science Center 217


Drexel University College of Medicine,
PhD, 2013.

Research Interests

Organizational and functional properties of the central monoaminergic projection systems and how they adapt in response to stress


(Updated March 2018)

  1. Borodovitsyna O, Flamini MD, Chandler DJ. Acute Stress Persistently Alters Locus Coeruleus Function and Anxiety-like Behavior in Adolescent Rats. Neuroscience, 373: 7-19, March 2018.
  2. Prouty EW, Chandler DJ, Waterhouse BD. Neurochemical differences between target-specific populations of rat dorsal raphe projection neurons. Brain Res, 1675: 28-40, November 2017.
  3. Prouty EW, Waterhouse BD, Chandler DJ. Corticotropin releasing factor dose-dependently modulates excitatory synaptic transmission in the noradrenergic nucleus locus coeruleus. Eur J Neurosci, 45(5); 712-22, March 2017.
  4. Waterhouse BD, Chandler DJ. Heterogeneous organization and function of the central noradrenergic system. Brain Res, 1641(Pt B): v-x, June 2016.
  5. Chandler DJ. Evidence for a specialized role of the locus coeruleus noradrenergic system in cortical circuitries and behavioral operations. Brain Res, 1641(Pt B): 197-206, June 2016
  6. Chandler DJ, Waterhouse BD, Gao WJ. New perspectives on catecholaminergic regulation of executive circuits: evidence for independent modulation of prefrontal functions by midbrain dopaminergic and noradrenergic neurons. Front Neural Circuits, 8(53), 1-10, May 2014.
  7. Chandler DJ, Gao WJ, Waterhouse BD. Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices. Proc Natl Acad Sci, 111(18): 6816-21, May 2014.
  8. Chandler DJ. Something's got to give: psychiatric disease on the rise and novel drug development on the decline. Drug Discov Today,18(3-4): 202-6, February 2013.
  9. Chandler DJ, Lamperski CS, WaterhouseBD. Identification and distribution of projections from monoaminergic and cholinergic nuclei to functionally differentiated subregions of prefrontal cortex. Brain Res, 1522: 38-58, 2012.

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