Molecular Biology

Eric Moss PhD

Faculty and Research Interests

Eric G. Moss, PhD

Associate Professor
856 566-2896
Fax: 856 566-6291
Science Center 312


Columbia University, NY
PhD (Microbiology) , 1990

University of Rochester, NY
BS (Microbiology) , 1984

Research Interests

We are investigating how development is controlled in the fourth dimension. Animals posses explicit genetic regulatory mechanisms that control the timing and synchrony of developmental events. Interestingly, the molecules involved are unlike other developmental patterning regulators and often involve post-transcriptional gene regulation. Most prominent among these unusual regulators are the microRNAs which were discovered in the developmental timing pathway of the nematode C. elegans. We are combining biochemistry, molecular biology and genetics to dissect and explore the developmental timing mechanism.

We discovered that Lin-28, an RNA-binding protein and a key developmental timing regulator of C. elegans, is conserved from worms to humans. It appears to be a timing regulator in many developmental events in the mouse and to be regulated by microRNAs through its 3' untranslated region. We are using the power of mouse molecular and developmental biology to extend our understanding of timing from worms to mice and humans.

Recent Publications


1. Tsialikas J, Romens MA, Abbott A, Moss EG. Stage-Specific Timing of the microRNA Regulation of lin-28 by the Heterochronic Gene lin-14 in Caenorhabditis elegans. Genetics. 2017 Jan;205(1):251-262. doi: 10.1534/genetics.116.195040.
Epub 2016 Nov 4. PubMed PMID: 27815363; PubMed Central PMCID: PMC5223506.

2. Yang M, Yang SL, Herrlinger S, Liang C, Dzieciatkowska M, Hansen KC, Desai R, Nagy A, Niswander L, Moss EG, Chen JF. Lin28 promotes the proliferative capacity of neural progenitor cells in brain development. Development. 2015 May 1;142(9):1616-27. doi: 10.1242/dev.120543. PubMed PMID: 25922525; PubMed Central
PMCID: PMC4419280.

3. Moss EG, Romer-Seibert J. Cell-intrinsic timing in animal development. Wiley Interdiscip Rev Dev Biol. 2014 Sep-Oct;3(5):365-77. doi: 10.1002/wdev.145. Epub
2014 Jul 24. Review. PubMed PMID: 25124757.

4. Rougvie AE, Moss EG. Developmental transitions in C. elegans larval stages.
Curr Top Dev Biol. 2013;105:153-80. doi: 10.1016/B978-0-12-396968-2.00006-3.
Review. PubMed PMID: 23962842.

5. Shinoda G, Shyh-Chang N, Soysa TY, Zhu H, Seligson MT, Shah SP, Abo-Sido N, Yabuuchi A, Hagan JP, Gregory RI, Asara JM, Cantley LC, Moss EG, Daley GQ. Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells. 2013 Aug;31(8):1563-73. doi: 10.1002/stem.1423. PubMed PMID: 23666760; PubMed Central PMCID: PMC3775935.

6. Shinoda G, De Soysa TY, Seligson MT, Yabuuchi A, Fujiwara Y, Huang PY, Hagan JP, Gregory RI, Moss EG, Daley GQ. Lin28a regulates germ cell pool size and fertility. Stem Cells. 2013 May;31(5):1001-9. doi: 10.1002/stem.1343. PubMed PMID: 23378032; PubMed Central PMCID: PMC3652309.

7. Vadla B, Kemper K, Alaimo J, Heine C, Moss EG. lin-28 controls the succession of cell fate choices via two distinct activities. PLoS Genet. 2012;8(3):e1002588.
doi: 10.1371/journal.pgen.1002588. Epub 2012 Mar 22. PubMed PMID: 22457637; PubMed Central PMCID: PMC3310729.

8. Balzer E, Heine C, Jiang Q, Lee VM, Moss EG. LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro.
Development. 2010 Mar;137(6):891-900. doi: 10.1242/dev.042895. PubMed PMID:

9. Balzer E, Moss EG. Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules. RNA Biol. 2007 Jan-Mar;4(1):16-25.
Epub 2007 Apr 30. PubMed PMID: 17617744.

10. Moss EG. Heterochronic genes and the nature of developmental time. Curr Biol.
2007 Jun 5;17(11):R425-34. Review. PubMed PMID: 17550772.

11. Polesskaya A, Cuvellier S, Naguibneva I, Duquet A, Moss EG, Harel-Bellan A.
Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency. Genes Dev. 2007 May 1;21(9):1125-38. PubMed PMID:
17473174; PubMed Central PMCID: PMC1855237.

We are pleased to announce a new program: Master of Science in Histopathology. In response to increased demand for highly competent technicians in translational research, we have developed this unique, hands-on program to prepare students to conduct biomedical research, including basic molecular and cell biology techniques, as well as the processing and analysis of primary tissue, in translational research. (read more!)

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