Molecular Biology

Welcome

The Molecular Biology faculty conduct research in genetics, gene regulation, DNA replication and repair, microRNAs, development and fertility, mitochondria function, cancer biology and cellular stress.

Department faculty teach Biochemistry, Microbiology, and Histology in the basic science curriculum of the School of Osteopathic Medicine. The faculty also comprise part of the Graduate School of Biomedical Sciences in Stratford, presenting courses such as Stem Cell Biology, Cancer Biology, Genetics, and Bioinformatics. Faculty mentors sponsor the research conducted by doctoral and masters thesis candidates in the Graduate School. Research in the Department is funded by the NIH, NSF, American Cancer Society, The W.W. Smith Foundation, the Foundation of UMDNJ, and other public and private organizations.

 

Publication Highlights

  • Jin, C., Strich, R. and Cooper, K.F. (2014) Slt2p phosphorylation induces cyclin C nuclear to cytoplasmic translocation in response to oxidative stress. Mol Biol Cell Epub Feb. 19: 2014; doi:10.1091/mbc.E13-09-0550

  • Cooper, K. F, Khakhina, S,. Kim, S. K. and Strich, R. (2014) Stress-Induced Nuclear to Cytoplasmic Translocation of Cyclin C Promotes Mitochondrial Fission in Yeast. Dev Cell 28: 161–173. PMID: 24439911.

  • Law MJ, Mallory MJ, Dunbrack RL Jr, Strich R. Acetylation of the transcriptional repressor Ume6p allows efficient promoter release and timely induction of the meiotic transient transcription program in yeast. Mol Cell Biol (2014) Feb;34(4):631-42


  • Shulga N, Pastorino JG. Mitoneet mediates TNFα induced necroptosis promoted by fructose and ethanol exposure. Journal of Cell Science (2013) 2013 Dec 19. [Epub ahead of print]

  • Wei, Q., Shen, Y., Chen, X., Shifman, Y. and Ellis, R. E. Rapid creation of forward-genetics tools for C. briggsae using TALENs: lessons for non-model organisms. Mol. Biol. Evol. first published online November 5, 2013 doi:10.1093/molbev/mst213

    Jin, C., A.K. Parshin, R. Strich, and K.F. Cooper Cyclin C connects stress sensors to programmed cell death in yeast. Oxidative Medicine and Cellular Longevity Epub
    dx.doi.org/10.1155/2013/320823. PMID: 24260614

  • Law, M.J., Lee D. S., Lee C. S., Anglim P. P., Haworth I. S., and Laird-Offringa, I.A. . The role of the C-terminal helix in the interaction of U1A protein with U1hpII RNA. Nucleic Acids Research 7092–7100 Nucleic Acids Research, 2013, Vol. 41, No. 14 Published online 22 May 2013 doi:10.1093/nar/gkt326

    Krishnan, H., Ochoa-Alvarez, J.A., Shen, Y., Nevel, E., Lakshminarayanan, M., Williams, M.C., Ramirez, M.I., Miller, W.T., Goldberg, G.S. Serines in the Intracellular Tail of Podoplanin (PDPN) Regulate Cell Motility. (2013) Journal of Biological Chemistry 288, 12215-12221

    Ellis, R. E. and Chen, X Sex determination: How worms count to two. Current Biology (2013) 23: R573-R575

    Guo, Y., Chen, X. and Ellis, R. E. Evolutionary Change Within a Bipotential Switch Shaped the Sperm/Oocyte Decision in Hermaphroditic Nematodes. (2013) PLoS Genet 9: e1003850.

    Tan GS, Lewandowski R, Mallory MJ, Strich R, Cooper K.F. Mutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic develoment in yeast Cell Div. (2013) Jul 1;8(1). PMID 23816140

    Jin, C., Parshin, AK, Daly, I. Strich R. and Cooper, K.F. The cell wall sensors Mtl1, Wsc1, Mid2 are required for stress-induced nuclear to cytoplasmic translocation of cyclin C and programmed cell death in yeast. Oxidative Medicine and Cellular Longevity In Press - 9/11/13

    Neary, C.L. and J.G. Pastorino Akt inhibition promotes hexokinase 2 redistribution and glucose uptake in cancer cells J. Cell Physiol. (2013) 228:1943-1948

     

     

 

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