Progress through research and mentoring.
Our faculty utilize a variety of model systems, such as yeast, C. elegans, mammalian cells and mice to study fundamental mechanisms of molecular and cellular biology. Our interests deal with questions addressing genetic pathways that regulate cell proliferation, cell fate, differentiation and cancer formation.
We pride ourselves in our teaching commitment and are involved in extensive teaching to graduate students as well as medical students.
Faculty mentors also host students every summer through Graduate School of Biomedical Sciences summer undergraduate research experience (SURE) and summer medical research fellowship programs (SMRF).
Our new home with Rowan University has presented many new opportunities for combined undergraduate/graduate accelerated programs leading to combined B.A and Masters degrees.
Jin, C., Strich, R. and Cooper, K.F. (2014) Slt2p phosphorylation induces cyclin C nuclear to cytoplasmic translocation in response to oxidative stress. Mol Biol Cell Epub Feb. 19: 2014; doi:10.1091/mbc.E13-09-0550
Cooper, K. F, Khakhina, S,. Kim, S. K. and Strich, R. (2014) Stress-Induced Nuclear to Cytoplasmic Translocation of Cyclin C Promotes Mitochondrial Fission in Yeast. Dev Cell 28: 161–173. PMID: 24439911.
Law MJ, Mallory MJ, Dunbrack RL Jr, Strich R. Acetylation of the transcriptional repressor Ume6p allows efficient promoter release and timely induction of the meiotic transient transcription program in yeast. Mol Cell Biol (2014) Feb;34(4):631-42
Shulga N, Pastorino JG. Mitoneet mediates TNFα induced necroptosis promoted by fructose and ethanol exposure. Journal of Cell Science (2013) 2013 Dec 19. [Epub ahead of print]
Wei, Q., Shen, Y., Chen, X., Shifman, Y. and Ellis, R. E. Rapid creation of forward-genetics tools for C. briggsae using TALENs: lessons for non-model organisms. Mol. Biol. Evol. first published online November 5, 2013 doi:10.1093/molbev/mst213
Jin, C., A.K. Parshin, R. Strich, and K.F. Cooper Cyclin C connects stress sensors to programmed cell death in yeast. Oxidative Medicine and Cellular Longevity Epub
dx.doi.org/10.1155/2013/320823. PMID: 24260614
Law, M.J., Lee D. S., Lee C. S., Anglim P. P., Haworth I. S., and Laird-Offringa, I.A. . The role of the C-terminal helix in the interaction of U1A protein with U1hpII RNA. Nucleic Acids Research 7092–7100 Nucleic Acids Research, 2013, Vol. 41, No. 14 Published online 22 May 2013 doi:10.1093/nar/gkt326
Krishnan, H., Ochoa-Alvarez, J.A., Shen, Y., Nevel, E., Lakshminarayanan, M., Williams, M.C., Ramirez, M.I., Miller, W.T., Goldberg, G.S. Serines in the Intracellular Tail of Podoplanin (PDPN) Regulate Cell Motility. (2013) Journal of Biological Chemistry 288, 12215-12221
Ellis, R. E. and Chen, X Sex determination: How worms count to two. Current Biology (2013) 23: R573-R575
Guo, Y., Chen, X. and Ellis, R. E. Evolutionary Change Within a Bipotential Switch Shaped the Sperm/Oocyte Decision in Hermaphroditic Nematodes. (2013) PLoS Genet 9: e1003850.
Tan GS, Lewandowski R, Mallory MJ, Strich R, Cooper K.F. Mutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic develoment in yeast Cell Div. (2013) Jul 1;8(1). PMID 23816140
Jin, C., Parshin, AK, Daly, I. Strich R. and Cooper, K.F. The cell wall sensors Mtl1, Wsc1, Mid2 are required for stress-induced nuclear to cytoplasmic translocation of cyclin C and programmed cell death in yeast. Oxidative Medicine and Cellular Longevity In Press - 9/11/13
Neary, C.L. and J.G. Pastorino Akt inhibition promotes hexokinase 2 redistribution and glucose uptake in cancer cells J. Cell Physiol. (2013) 228:1943-1948