Faculty & Research Interests
Barry D. Waterhouse, PhD
Professor & Chair
Science Center Building, Lab 225
Temple University, School of Medicine,
Department of Pharmacology, PhD, 1978
The primary research focus of my laboratory is to understand the role of the central monoaminergic systems in brain function and behavior. More specifically we are concerned with the anatomy, physiology, and molecular biology of the brainstem noradrenergic and serotonergic efferent systems as they relate to executive functions and the sensory processing capabilities of the organism. These studies employ a broad spectrum of neuroanatomical, electrophysiological, and molecular profiling techniques including single and multi-unit extracellular recording from anesthetized and waking animals, computer based acquisition and analysis of spike train data, mapping of monoamine projections from source nuclei using retrograde tracer substances, single cell laser capture and qRT-PCR profiling of specific neuronal sub-types. The underlying theme of this work is that synaptically released norepinephrine and serotonin operate in mammalian brain as complimentary neuromodulatory substances; regulating the responsiveness of neurons and circuits along sensory pathways and within local networks of the prefrontal cortex that are innervated by noradrenergic and serotonergic systems. As such these systems may play a significant role in the ability of the organism to orient and attend to novel or salient stimuli from the sensory surround and adopt appropriate behavioral responses to these stimuli. The clinical implications of this work include: 1) the neurobiological basis of stress and anxiety disorders including
PTSD and depression, 2) clinically approved and off-label use of psychostimulant drugs (methylphenidate) for treatment of attention disorders and cognitive enhancement, respectively.
(Updated January 2017)
- Navarra RL, Clark BD, Gargiulo AT, Waterhouse BD. Methylphenidate Enhances Early-Stage Sensory Processing and Rodent Performance of a Visual Signal Detection Task. Neuropsychopharmacology, 1-12, January 2017.
- Prouty EW, Waterhouse BD, Chandler DJ. Corticotropin releasing factor dose-dependently modulates excitatory synaptic transmission in the noradrenergic nucleus locus coeruleus. Eur J Neurosci, 1-11, December 2016.
- Bradshaw SE, Agster KL, Waterhouse BD, McGaughy JA. Age-related changes in prefrontal norepinephrine transporter density: The basis for improved cognitive flexibility after low doses of atomoxetine in adolescent rats. Brain Res, 1641(Pt B): 245-57, June 2016.
- Waterhouse BD, Chandler DJ. Heterogeneous organization and function of the central noradrenergic system. Brain Res, 1641(Pt B): v-x, June 2016.
- Chu R, Shumsky J, Waterhouse BD. Differentiation of rodent behavioral phenotypes and methylphenidate action in sustained and flexible attention tasks. Brain Res, 1641(Pt B): 306-19, June 2016.
- Festa L, Gutoskey CJ, Graziano A, Waterhouse BD, Meucci O. Induction of Interleukin-1β by Human Immunodeficiency Virus-1 Viral Proteins Leads to Increased Levels of Neuronal Ferritin Heavy Chain, Synaptic Injury, and Deficits in Flexible Attention. J Neurosci, 35(29): 10550-61, July 2015.
- Bhattacharya SE, Shumsky JS, Waterhouse BD. Attention enhancing effects of methylphenidate are age-dependent. Exp Gerontol, 61: 1-7, January 2015.
- Chandler DJ, Waterhouse BD, Gao WJ. New perspectives on catecholaminergic regulation of executive circuits: evidence for independent modulation of prefrontal functions by midbrain dopaminergic and noradrenergic neurons. Front Neural Circuits, 8: 53, 1-10, May 2014.
- Chandler DJ, Gao WJ, Waterhouse BD. Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices. Proc Natl Acad Sci, 111(18): 6816-21, May 2014.
- Vasudeva RK, Waterhouse BD. Cellular profile of the dorsal raphe lateral wing sub-region: relationship to the lateral dorsal tegmental nucleus. J Chem Neuroanat, 57-58: 15-23, May 2014.
- Zitnik GA, Clark BD, Waterhouse BD. Effects of intracerebroventricular corticotropin releasing factor on sensory-evoked responses in the rat visual thalamus. Brain Res, 1561: 35-47, May 2014.
- Navarra RL, Clark BD, Zitnick GA, Waterhouse BD. Methylphenidate and atomoxetine enhance sensory-evoked neuronal activity in the rat visual thalamus. Exp Clin Psychopharmacol, 21 (5): 363-74, October 2013.
- Wang H-X, Waterhouse BD, Gao W-J. Selective suppression of excitatory
synapses on GABAergic interneurons by norepinephrine in juvenile prefrontal cortical
microcircuitry. Neuroscience, 246: 312-28, August 2013.
- Agster KL, Meijas-Aponte C, Dyutin D, Clark B, and Waterhouse BD. Evidence for a regional specificity in the density and distribution of noradrenergic varicosities in rat. J Comp Neurol, 521(10): 2195-207, July 2013.
- Chandler DJ, Lamperski CS, Waterhouse BD. Identification and distribution of
projections from monoaminergic and cholinergic nuclei to functionally differentiated
subregions of prefrontal cortex. Brain Res, 1522: 38-58, July 2013.
- Zitnik GA, Clark BD, Waterhouse BD. The impact of hemodynamic stress on s
ensory signal processing in the rodent lateral geniculate nucleus. Brain Res, 1518: 36- 47, June 2013.
- Urban KR, Waterhouse BD, Gao W-J. Distinct age-dependent effects of
methylphenidate on developing and adult prefrontal neurons. Biol Psychiatry, 72(10): 880-8, November 2012.