Professor & Chair; Cell Biology & Neuroscience
Rowan Medicine Building, Suite 2200, 856-566-6407
Science Center 225, 856-566-6039
- Role of the central monominergic systems in brian function & behavior.
Professor, Senior Associate Dean for
Research & Graduate School of Biomedical Sciences
- Effect of humoral mediators and inflammatory cells in the pathophysiology of ischemic states
- Effects of dietary lipids on cardiovascular function
- Response of the young and aging heart to ischemia and reperfusion
Science Center 207B
- Mechanisms of transcription
- RNA polymerase structure and function; mitochondrial transcription
- Molecular mechanisms of transcription and its regulation
- Structure and function of bacterial transcription factors GreA, GreB, Gfh1 and DksA that modulate the catalytic activities of RNA polymerase
- Regulation of adrenocortical function in lizards and birds
- Mechanisms of adrenocortical remodeling with stress and endocrine alterations
Science Center 222
- Cellular correlates of executive function in the prefrontal cortex.
- Effects of psychostimulant drugs on sensory & cognitive circuit functions.
- Strategies to reduce cognitive effort in a signal detection task.
Science Center 217
- Organizational & functional properties of the central monoaminergic projection systems.
- How central monoaminergic projection systems adapt in response to stress.
- Pathogenic mechanisms underlying neurodegenerative diseases in an effort to identify avenues of therapeutic intervention
- Gene and cell-based therapies in animal models of disease to create a foundation for possible clinical application
- Functions of microRNA and other related short RNAs in embryonic stem cells during early embryogenesis in the mouse.
- Pathophysiology of Canavan Disease and Metachromatic leukodystrophy
- Gene therapy of neurodegenerative diseases
- Inflammation induced by ischemia/reperfusion of individual organs (the heart or liver in rats), and the role of the various inflammatory mediators.
- Role of nitric oxide in the modulation of activation of apoptosis pathways in the rat model of myocardial ischemia-reperfusion.
- Factors that regulation yeast mitochondrial transcription in response to stress.
- Mitochondrial metabolism and migration in neural tissue.
- Regulation of catecholamine storage in response to neurostimulants.
- Cell aging, cell senescence and cancer.
- Pathogenesis of Alzheimer's Disease.
Science Center 226
- Effects of catecholamine neurotransmission on electrophysiological indices of sensory signal processing.
- Effects of performance enhancing drugs on behavior in preclinical rodent models of cognition.
- The impact of the locus coeruleus-norepinephrine system on sensory-guided goal-directed behaviors.
- Mechanisms of ribosome assembly
- Ribosome biogenesis in mammalian cells
Rowan Medicine Building, Suite 2200A
- Course Director of Medical Physiology.
- Teaches Endocrine Pharmacology.
- Lecturer in the Graduate School in Exercise Physiology, Pharmacology and Fundamentals of Systems Biology.
- Investigation of mechanisms of ribosome degradation in Saccharomyces cerevisiae.
- Regulation of protein expression via ubiquitination.
- Synthesis and biological activities of lipid mediators of inflammation: Isoprostanes, Neuroprostanes, Phytoprostanes, Leukotrienes and Prostaglandins
- Synthesis of lipid mediators of resolution: Lipoxins, Resolvins, Neuroprotectins and Maresins
- Clinical studies in areas of inflammation including Autism, Asthma and Alzheimer's disease.
- RNA polymerase structure and function
- Regulation of transcription.
- Cell communication – how cells receive signals and decipher them to respond in an appropriate fashion
- Communication in neuronal cells – both central and peripheral
Adjunct Associate Professor
Rowan Medicine Building, Suite 2200
- Inflammation resolution in sepsis.
- Beneficial effects of Lipoxin A4 in resolving inflammation during sepsis.