Professor and Chair
Science Center 120
My laboratory is interested in the post-translational mechanisms that regulate the proteins involved in base-excision repair of DNA. We are studying the aberrant pathways that lead to uracil misincorporation into DNA as well as the regulated cytosine deamination pathways of the APOBEC family of cytosine deaminases.
Science Center 306A
Our laboratory is interested in dissecting the mechanisms of DNA replication in prokaryotic and eukaryotic systems with goals of developing novel anti-microbials and anti-proliferation drugs.
Science Center, Room 362
Following stress cells have to orchestrate a myriad of responses to survive or die. Incorrect choices can led to deleterious outcomes, e.g. tumor formation. To study this, we use S. cerevisiae, human cells and mouse models. We focus on the conserved cyclin C protein that is destroyed in response to stress. Our working hypothesis is that cyclin C is a novel stress related tumor suppressor.
Science Center 276
Acute lymphoblastic leukemia (ALL) is a neoplastic disorder of lymphoblasts that are committed to the B-cell lineage (B-ALL) or the T-cell lineage (T-ALL). Five-year survival rates (FSR) for children and adolescents with this disease are 75–85%, whereas, adult T-ALL patients have a 35–40% FSR. T-ALL patients have essentially the same FSR of patients with B-ALL. However, certain aspects about T-ALL make it a more aggressive disease with a poorer clinical outcome than B-ALL.
Science Center 316
Fax: 856 566-6291
Control of Germ Cell Fate: Animals must produce sperm or eggs to reproduce. Although these cell types differ dramatically, they are produced from similar progenitors. Understanding how this process is controlled could revolutionize our ability to treat reproductive disorders and infertility in humans. Evolution of Hermaphroditism: Sexual traits are among the most rapidly changing features of each species. To learn how these changes take place, and how developmental pathways constrain which ones occur, we are studying the evolution of mating systems in nematodes.
Science Center 128
Medical schools employ a variety of curricula to educate students to be competent physicians. Currently we are evaluating the role and value of biomedical knowledge in clinical reasoning and diagnosing by obtaining feedback from practicing physicians. I also focus on understanding and utilizing educational technologies such as exam software, online learning management systems and virtual programs to enhance student learning.
Science Center B307
Cells must communicate with each other to coordinate the development and survival of an animal. This communication can be mediated by diffusible factors that pass between cells, or by direct contact through cell junctions. I am interested in how intercellular communication affects cell growth and differentiation, with an emphasis on how cell communication can control tumor cell growth and prevent eye diseases.
Science Center 320
Research in the laboratory is focused on evolutionarily conserved mitochondrial translational activators, using yeast as a model system. Defects in mitochondrial gene expression can compromise cellular energy production and generate reactive oxygen species that promote degenerative disease, aging and cancer.
Science Center, Room 122
My research is focused on understanding how transcriptional control regulates cell fate decisions. Cells that are presented with an environmental challenge must respond in a manner that is appropriate for the stimulus. Using the budding yeast Saccharomyces cerevisiae as a model system, my work focuses on post-translational histone modifications during metabolic challenge and differentiation.
Associate ProfessorA novel approach to the study of globin gene switching:
University Doctors Pavilion, 2214
- Translational control
- Structural features that modulate efficiency of translation of mRNA
- Apoptosis in leukemia cells and its application to cancer therapy
- Organizational of chromosomes in the nucleus (in collaboration with Dr. R. Nagele)
Science Center 312
We study developmental timing, microRNAs and translational control in C. elegans and the mouse. The worm heterochronic gene lin-28 is regulated by microRNAs and encodes a specific mRNA-binding protein. Its human homologue, Lin28, appears also to be a microRNA-controlled developmental regulator.
Science Center 130
Research in the laboratory focuses on the repair of uracil in DNA, which is critical for the maintenance of genomic integrity. Specifically we are elucidating transcriptional and post-translational pathways that regulate expression of uracil-DNA glycosylase under normal cellular conditions and in response to anti-tumor agents.
Hexokinase II (HK2), which catalyzes the first committed step of glycolysis, is overexpressed in many cancers. When inhibited, HK2 translocates from the mitochondria to the nucleus. I am investigating the signaling pathways that mediate HK2 mitochondrial association and nuclear translocation.
Our work identifies distinctions in mitochondrial function between normal and cancerous cells for the potential discovery of novel chemotherapeutic targets that can be exploited to selectively induce cytotoxicity in cancer cells. Mitochondrial injury is also central to number of disease states.
Science Center 354
Cyclin C is a transcription factor normally found in the nucleus. In response to cellular damage, cyclin C relocates to the mitochondria and promotes mitochondrial fragmentation and apoptosis. My laboratory utilizes multiple systems including yeast, mammalian cell culture and knockout mouse models to understanding the role of conserved C-type cyclin in mitochondrial dynamics and tumor suppression.