Faculty and Research Interests
Catherine L. Neary, PhD
Science Center 316
Fax: 856 566-6291
Thomas Jefferson University, Philadelphia, PA
PhD (Pathology and Cell Biology), 2000
Purdue University, West Lafayatte, IN
B.S. (Biological Sciences), 1994
Hexokinase II (HK2), which catalyzes the first committed step of glycolysis, is overexpressed in many cancers. When inhibited, HK2 translocates from the mitochondria to the nucleus. I am investigating the signaling pathways that mediate HK2 mitochondrial association and nuclear translocation.
- Neary, C.L. and J.G. Pastorino. Akt Inhibition Promotes Hexokinase 2 Redistribution and Glucose Uptake in Cancer Cells. Journal of Cellular Physiology (2013) 228: 1943-1948.
- Neary, C.L., and J.G. Pastorino. Nucleocytoplasmic shuttling of hexokinase II in a cancer cell. Biochemical and Biophysical Research Communications (2010) 394(4):1075-1081.
- Gupta, S., Cuffe, L., Szegezdi, E., Logue, S.E., Neary, C., Healy, S., and A. Samali. Mechanisms of ER stress-mediated mitochondrial membrane permeabilization. International Journal of Cell Biology (2010) 2010:170215.
- Neary, C.L., Nesterova, M., Cho, Y.S., Cheadle, C., Becker, K., and Y.S. Cho-Chung. Protein Kinase A isozyme switching: eliciting differential cAMP signaling and tumor reversion. Oncogene (2004) 23(54):8847-56.
- Bree, R.T., Neary, C., Samali, A., and N.F. Lowndes. The switch from survival responses to apoptosis after chromosomal breaks. DNA Repair (Amst). (2004) 3(8-9):989-95.
- Cho, Y.S., Kim, M.K., Cheadle, C., Neary, C., Park Y.G., Becker, K.G., and Y.S. Cho-Chung. A genomic-scale view of the cAMP response element-enhancer decoy: a tumor target-based genetic tool. Proceedings of the National Academy of the Sciences, U.S.A. (2002) 99:15626-31.
- Cho-Chung, Y.S., Nesterova, M., Becker, K.G., Srivastava, R., Park Y.G., Lee, Y.N., Cho, Y.S., Kim, M.K., Neary, C., and C. Cheadle. Dissecting the circuitry of protein kinase A and cAMP signaling in cancer genesis: antisense, microarray, gene overexpression, and transcription factor decoy. Annals of the N.Y. Academy of the Sciences (2002) 968:22-36.
- Neary, C.L. and Y.S. Cho-Chung. Nuclear Translocation of the Catalytic Subunit of Protein Kinase A Induced by an Antisense Oligonucleotide Directed Against the RIα Subunit. Oncogene (2001) 20:8019-8024.
- Cho, Y.S., Kim, M.K., Cheadle, C., Neary, C., Becker, K.G., and Y.S. Cho-Chung. Antisense DNAs as Multisite Genomic Modulators Identified By DNA Microarray. Proceedings of the National Academy of the Sciences, U.S.A. (2001) 98:9819-9823.